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Evidence-Based Practice

APHON's Evidence-Based Practice and Research Committee supports the development of Evidence-Based Practice Guidelines and supports research activities within the membership optimizing outcomes for children, adolescents and young adults with cancer and blood disorders.

Clinical Guidelines

The APHON Evidence-Based Practice and Research Committee has reviewed these guidelines and recommends them as appropriate for APHON members:

American Brain Tumor Association/American Association of Neuroscience Nurses

Date of Publication: 2014 | Date of Initial Review: June 2014 | Continued APHON Endorsement: 2019

Care of the Pediatric Patient with a Brain Tumor AANN Clinical Practice Guideline Series

Children's Oncology Group

Date of Publication: 2018 | Date of Review: July 30, 2018

Assessment Tools for Peripheral Neuropathy in Pediatric Oncology: A Systematic Review from the Children’s Oncology Group

Date of Publication: 2017 | Date of Review: January 2019

From the Children’s Oncology Group: Evidence-Based Practice Recommendations for Peg-Asparaginase Nurse Monitoring, Hypersensitivity Reaction Management, and Patient/Family Education

The APHON EBP/Research Committee is proud to list the endorsed Supportive Care Guidelines as a resource for pediatric oncology nurses. A multi-disciplinary group of the Supportive Care Committee within COG has very stringently reviewed these guidelines and endorsed them.

Date of Publication: 2018 |  Reviewed & Endorsed: 2019

Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline

Date of Publication: 2011 | Reviewed and Endorsed: 2018

Guideline for Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients

Date of Publication: 2014 | Reviewed and Endorsed: 2014

Guideline for the Prevention and Treatment of Anticipatory Nausea and Vomiting due to Chemotherapy in Pediatric Cancer Patients

Date of Publication: 2016  Reviewed and Endorsed: 2016

Guideline for the Treatment of Breakthrough and Prevention of Refractory Chemotherapy-induced Nausea and Vomiting in Pediatric Cancer Patients

Date of Publication: 2018 | Reviewed and Endorsed: 2019

Guideline for the Management of Clostridium Difficile Infection in Children and Adolescents with Cancer and Pediatric Hematopoietic Stem-Cell Transplantation Recipients

Date of Publication: 2018 | Reviewed and Endorsed: 2018

Management of fatigue in children and adolescents with cancer and in paediatric recipients of haematopoietic stem-cell transplants: a clinical practice guideline

Date of Publication: 2016 | Reviewed and Endorsed: 2016

Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation

Date of Publication: 2015 | Reviewed and Endorsed: 2016

Guidance on Platelet Transfusion for Patients with Hypoproliferative Thrombocytopenia

Journal of Clinical Oncology

Date of Publication: 2017 | Date of Review: October 2019

Guidelines for the Management of Fever and Neutropenia in Children with Cancer and Hematopoietic Stem Cell Transplantation Recipients: 2017 Update

Journal of Pediatric Oncology Nursing

Date of Publication: 2019 | Date of Review: June 8, 2020

Evidence-Based Recommendations for the Appropriate Level of Sedation to Manage Pain in Pediatric Oncology Patients Requiring Procedures: A Systematic Review From the Children’s Oncology Group

Date of Publication: 2014 | Date of Review: March 4, 2018

Evidence-Based Practice Recommendations for Hydration in Children and Adolescents with Cancer Receiving Intravenous Cyclophosphamide

Date of Publication: 2014 | Date of Review: May 10, 2018

Evidence-Based Practice Recommendations to Prevent/Manage Post Lumbar Puncture Headaches in Pediatric Patients Receiving Intrathecal Chemotherapy

Date of Publication: 2014 | Date of Review: April 2, 2018

Evidence-Based Practice Recommendations to Fertility Preservation Options for Inclusion in Treatment Protocols for Pediatric and Adolescent Patients Diagnosed with Cancer

The National Consensus Project for Quality Palliative Care

Date of Publication: 2018 | Date of Review: November 30, 2018

Clinical Practice Guidelines for Quality Palliative Care, 3rd edition

National Heart, Lung, and Blood Institute

Date of Publication: September 2014 | Date of Review: December 2017

Evidence-Based Management of Sickle Cell Disease: Expert Panel Report

Oncology Nursing Society (ONS)

Date of Publication: February 2017 | Date of Review: Fall 2018

PEP Topic: Constipation

PEP Topic: Anorexia

Date of Publication: April 2017 | Date of Review: March 2018

PEP Topic: Anxiety

Date of Publication: April 2017 | Date of Review: January 2018

PEP Topic: Chemotherapy-Induced Nausea and Vomiting-Pediatric

PEP Topic: Prevention of Infection

Date of Publication: May 2017  | Date of Review: January 2018

PEP Topic: Mucositis

Pediatric Blood & Cancer

Date of Publication: 2017 | Date of Review: March 31, 2019

Guideline for the Prevention of Acute Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients: A Focused Update

Resources for developing an Evidenced Based Practice Project

Duke University EBP tutorial | American Nursing Association EBP Toolkit | University of Maryland Evidenced-Based Practice Site

Research Tools

The Cochrane Database | US National Library/ National Institutes of Health | Turning Research into Practice

Additional Resource