The APHON Pediatric Chemotherapy-Biotherapy Provider Renewal Program provides ongoing education for current APHON Chemotherapy and Biotherapy Providers as they gain specific knowledge, according to national standards, that is needed to safely and consistently administer chemotherapy and biotherapy to children and adolescents.
To ensure that Pediatric Chemotherapy/Biotherapy Providers stay current in their knowledge of safe chemotherapy and biotherapy administration, APHON requires active Providers to renew their status every (2) two years after the completion and passing of their initial provider exam.
Program Overview
The 2026 Provider Renewal Exam opens October 1, 2026. The last day to complete the renewal exam is December 15, 2026.
Why does my exam need to be completed by December 15? Completion by this date ensures that all providers are successfully renewed and have certificates issued prior to the year end and holiday season which ensures no gap in your status.
The Renewal Exam is a 90-minute, open-note, online assessment comprising 25 questions in both English and Spanish, and it is accessible at any point during the open renewal season (October 1, 2026 through December 15, 2026). Participants are granted (2) two attempts to successfully pass the exam, thereby renewing their status for another (2) two-year duration. In the event that a participant is unable to pass the exam during the open renewal season, it will be necessary for them to retake the initial Provider Course to reinstate their status.
To view the current available public Provider Courses, please visit our Upcoming Provider Courses.
Nurses who expect to be on FLMA or military deployment during their renewal season may request an exam extension before January 15, 2027. After this date, you will be required to retake the initial Provider Course.
If you are unsure about the expiration date of your provider status, the APHON Education Team encourages you to log into your Provider associated account and review your Provider Card where your expiration is listed.
Access to the exam is limited to only those Providers with an expiration date of December 31, 2026 for the 2026 Renewal Cycle. The Exam may be purchased starting October 1, 2026.
After successfully passing your exam, all renewing Providers are required to complete a post-exam survey to receive their renewed Provider card and (2) two continuing nursing education (NCPD) contact hours listed on your completion certificate. If you are unable to achieve a passing score, your Provider status will expire upon the listed date, and you will be ineligible for the awarded NCPD credits. Should you require ILNA categories applied to your completion certificate, please contact the Education Team for further assistance.
Exam Preparation and Resources
APHON provides the following resources to all renewing Providers to prepare for their Renewal Exam. There is not a practice quiz for the Renewal Exam and your first attempt will be scored upon first entering the exam in your ACE Center. When taking your first attempt, APHON strongly recommends only beginning when you have a designated 90-minute window to complete your exam as once your exam begins, it cannot be paused, saved, or revisited and the timer will not stop until it is expired or you have submitted your completed answers. Please review both the Participation Guide and the Review Packet before your first exam attempt:
Exam Content and Learning Outcomes
- Photobiomodulation
- Infusion Reactions
- Blinatumomab
- We Are Nurses: A Research Review
You must achieve a minimum score of 80% to pass (20/25 correct answers). If you are unsuccessful in your first attempt, you will be permitted to retake the exam one time at no additional cost. If you do not achieve a passing score after (2) two attempts, you will be required to retake the 2-day Provider Course. Because the exam is open note, you are encouraged to actively use the Review Packet during your testing experience.
Learning Outcomes
As a result of participating in this educational activity, the learner will gain specific knowledge, according to national standards, that is needed to safely and consistently administer chemotherapy and biotherapy to children and adolescents. Post-testing and evaluations will evidence the measurement of this outcome of key concepts, including:
- Identify oral mucositis as a common dose-limiting side effect of cancer treatment for pediatric, adolescent, and young adult patients.
- Discuss the mechanism of photobiomodulation in the reduction of inflammation.
- Describe the barriers that should be addressed when developing a photobiomodulation program.
- Explain two ways that the immune system is involved in infusion reactions.
- Differentiate between symptoms of allergic reactions, anaphylaxis, and cytokine release syndrome.
- Describe nursing management of an infusion reaction, including three drugs commonly used during infusion reactions.
- Identify blinatumomab’s mechanism of action and immunotherapy classification.
- Recognize the nursing considerations for blinatumomab administration and special considerations.
- Identify the appropriate use of blinatumomab and future applications of the drug.
- Identify the purpose of research in Pediatric Hematology/Oncology.
- State basic research processes, terms, and concepts.
- Recognize “adverse events” and how they apply to research studies.
- Identify their own role in pediatric hematology/oncology research.
- Apply research understanding to a case study.
Renewal Exam Pricing, Fee Structures, and Bulk Order Invoicing
2026 Renewal Exam Cost
October Rate: $80 for Members | $105 for non-members
November/December Rate: $100 for members | $125 for non-members
Refunds and Cancellations
Once a book, course or any virtual or downloadable product is purchased from the Association of Pediatric Hematology Oncology Nurses (APHON), all sales are final. APHON does not offer refunds, exchanges or credit for any reason, including, but not limited to change of mind, dissatisfaction with content or purchasing error. No refunds will be given for renewal exams purchased but not completed by December 15, 2026, at 11:59 pm EST.
Bulk Renewal Orders
If you are interested in paying for a bulk renewal for the nurses at your institution or hospital, the APHON Education Team can assist you with the invoice. Invoices may be paid by credit card, check, or ACH payment. Once payment is received, a coupon code will be provided to apply for each individual 2026 Renewal Exam.
All requests for the October Early Bird Renewal Rate must be submitted by email to the APHON Education Team at education@aphon.org no later than October 15, 2026, and payment must be received and processed no later than October 27, 2025. All other requests for bulk renewal invoicing must be made prior to November 24, 2026, for the standard renewal rate and payment must be received no later than December 5, 2026.
After November 24, 2026, individual nurses will be responsible for purchasing their own Renewal Exam and institution-based invoicing will no longer be available for the 2026 Renewal Cycle.
US, Canada, and High-Income Countries
View US, Canada, and High-Income Countries
Aruba, Andorra, United Arab Emirates, American Samoa, Antigua and Barbuda, Austria, Belgium, Bahrain, Bahamas, The, Bermuda, Barbados, Brunei Darussalam, Canada, Switzerland, Channel Islands, Chile, Curaçao, Cayman Islands, Cyprus, Czechia, Germany, Denmark, Spain, Estonia, Finland, France, Faroe Islands, United Kingdom, Gibraltar, Greece, Greenland, Guam, Guyana, Hong Kong SAR, China, Croatia, Hungary, Isle of Man, Ireland, Iceland, Israel, Italy, Japan, St. Kitts and Nevis, Korea, Rep., Kuwait, Liechtenstein, Lithuania, Luxembourg, Latvia, Macao SAR, China, St. Martin (French part), Monaco, Malta, Northern Mariana Islands, New Caledonia, Netherlands, Norway, Nauru, New Zealand, Oman, Panama, Poland, Puerto Rico, Portugal, French Polynesia, Qatar, Romania, Saudi Arabia, Singapore, San Marino, Slovak Republic, Slovenia, Sweden, Sint Maarten (Dutch part), Seychelles, Turks and Caicos Islands, Trinidad and Tobago, Taiwan, China, Uruguay, United States, British Virgin Islands, Virgin Islands (U.S.))
October Rate: $80 for Members | $105 for non-members
November/December Rate: $100 for members | $125 for non-members
International Pricing
Pediatric Hematology/Oncology Nurses from World Bank Atlas defined upper-middle, low-middle, and low-income countries are eligible for a discount on the renewal exam. Please contact education@aphon.org to access this discount.
Provider Renewal Guidelines
How are Pediatric Chemotherapy/Biotherapy providers notified that they are due to renew their status?
All renewing providers receive multiple emails before and during the renewal period as notification they are due to renew their status.
Please be aware that, although APHON makes efforts to notify providers of their expiring status, it remains the responsibility of providers to maintain and renew their status promptly. Keeping your information up-to-date and regularly reviewing your provider card is the most effective way to prevent your status from lapsing. Additionally, we strongly recommend storing a copy of your NCPD certificates and provider card on a hard drive or a cloud-based storage system. Individual providers are responsible for the maintenance and storage of NCPD documentation and completion records.
When are pediatric Chemotherapy/Biotherapy providers eligible to renew their status?
Renewing providers whose status expires on December 31, 2026, will need to renew between October 1 and December 15th, 2026. The renewal exam must be completed by 11:59 pm US Eastern Time (UTC -5 hours) on December 15, 2026.
How much time do I have to complete the Pediatric Chemotherapy/Biotherapy renewal exam once I start?
You will have 90 minutes to complete the exam once you start. Once the exam timer begins, it will not pause or stop until all 25 questions have been submitted or the timer expires.
When is the deadline to complete the pediatric chemotherapy/biotherapy renewal exam?
The renewal exam must be completed by 11:59PM US Eastern Time (UTC -5 hours) on December 15, 2026.
**Note: Staff support will not be available to aid with technical issues on weekends or after core business hours (9:00 am EST until 4:00 pm EST Monday through Friday, except during holidays). We strongly encourage all providers to initiate the renewal process during normal business hours when staff will be available to provide support.
You will not be permitted to take the exam after 11:59 pm US Eastern Time (UTC -5 hours) on December 15, 2026, regardless if payment was submitted. Refunds will not be given. Additionally, no refunds will be given for failure to complete the exam by December 15, 2026, or failure to achieve a passing score on the exam.
Exams purchased but not completed by December 15 will be deactivated and flagged as expired starting January 1, 2026. We do not accept exam extension requests. Only FMLA or military deployment situations that occur during the renewal period are considered.
How do Pediatric Chemotherapy/Biotherapy Providers that previously completed the exam access their continuing nursing education certificate?
The certificate and updated provider card are available within the exam portal following completion of the post-exam evaluation. Your updated Provider Card can be found in ‘My Cards’ under the ‘My APHON’ drop-down menu and your NCPD completion certificate can be found under ‘Transcript and downloaded by clicking the icon of the corresponding exam.
For more detailed information about the Provider Renewal Program, please refer to the 2025 Chemotherapy and Biotherapy Renewal Exam Participant Guide.
Accreditation and Disclaimer
Pharmacology Content
This program may also be recognized for 1.2 hours of pharmacology content indicated as calculated by the APHON Pediatric Chemotherapy/Biotherapy Provider Program Committee. APHON does not award pharmacology credit. APHON recommends that attendees retain a copy of the certificate for supportive documentation to submit to your state’s nursing board. Please note that you may not apply NCPD to pharmacology content. The content may be used in only one area, nursing contact hours, or pharmacology content.
Official ONCC Statement and Disclaimer
The program content has been reviewed by the Oncology Nursing Certification Corporation (ONCC) and is acceptable for recertification points in the following areas:
Basic Concepts for Transplantation, Care Continuum, Care of the Pediatric Hematology and Oncology Patient, Coordination of Care, Diagnosis and Staging, Disease-Related Biology, Early Post-transplant Management, End-of-Life, Foundations of Transplant, Graft-versus-Host Disease Prevention Management, Health Promotion/Screening, and Early Detection, 0.00 Late Post-Traumatic Management, Oncology Nursing Practice, Quality of Life, Palliative Care, Pre-Transplant Care, Preparative Regimens, Professional Practice, Psychosocial, Roles of the APN, Scientific Basis for Practice, Survivorship, Symptom Management, Treatment, Types of Transplants and Sources of Stem Cells, 0.00 Oncologic Emergencies.
Disclaimer: ONCC review is only for designating content to be used for recertification points and is not for NCPD accreditation. NCPD programs must be formally approved for contact hours by an acceptable accreditor/approver of nursing NCPD to be used for recertification by ONCC. If the NCPD provider fails to obtain formal approval to award contact hours by an acceptable accrediting/approval body, no information related to ONCC recertification may be used in relation to the program.
Course content applies to multiple content areas across multiple credentials. Individual nurses’ learning plans are linked to the ONCC Test Blueprint for the certification they hold. Review the current test blueprint available on the ONCC website to determine where the content fits.
Accreditation Statement
Association of Pediatric Hematology/Oncology Nurses (APHON) is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.
Disclosure
A staff member, volunteer, or family member who has an affiliation with a commercial company must declare that relationship in advance of involvement with an educational activity that could be used as a forum to promote the interest of that company and its products. There are no disclosures to report for this activity.
AI Guidelines
The use of Artificial Intelligence (AI) tools (such as, but not limited to ChatGPT, Copilot, Claude, Curipod, Gamma, Global Goals, Jungle, Perplexity, or Quizlet) used to gain exam knowledge and complete the Chemotherapy Biotherapy examinations is not permitted.
For all other questions or concerns, please reach out to the APHON Education Team at education@aphon.org.